Portal/Hepatic Vein Embolisation treatment- A guide for patients

Introduction

This leaflet is designed for patients who have been advised to have a Portal Vein Embolisation (PVE)/ Hepatic Vein Embolisation (HVE).

What is a PVE/HVE?

• A PVE/HVE blocks off the blood supply to the diseased part of the liver. The PVE/HVE will cause the normal liver to grow to a size where the diseased part of the liver can then be safely removed in surgery.
• The larger normal liver segment that has grown should stop the complication of liver failure after the surgery.

Why do I need this procedure?

The PVE/HVE is needed to assist with your liver surgery. It will help to ensure that there is a larger amount of normal liver post-surgery.

Who has made the decision for me to have this procedure?

• The consultant in charge of your case and the radiologist performing the PVE/HVE will have discussed your case and come to the conclusion that this is the best way of treating your condition.
• You will have the opportunity for your opinion to be taken into account, and if after discussion with your doctors, you do not want the procedure carried out, you can decide against it.

Who will be performing the procedure and other staff you are likely to meet?

• A specially trained doctor called an Interventional Radiologist will be performing your procedure.
• Radiologists have special expertise in using x-ray equipment and in interpreting the images produced, as well as performing minimally invasive procedures.
• They will look at these images whilst carrying out the procedure.
• The Interventional Radiologist will be assisted by a radiographer and nurses and/or other Radiology doctors or trainees.

Where will the procedure take place?

You will be taken to the Interventional Radiology Department.

What happens before my procedure?

• You may be admitted to hospital on the day of, or the night before the procedure.
• A doctor will take a medical history from you.
• You may have a small needle put into a vein in your arm for painkillers to be given if necessary.
• Standard blood tests may be carried out.
• You may eat a light meal and drink as normal unless otherwise informed – in which case, you may be fasting for 4-6 hours prior.
• You may be given antibiotics or other pre-medication on the morning of the procedure if required.
• If you have any allergies you must let your doctor know and a red allergy band will be attached to your wrist.
• If you take any medications to thin the blood (anticoagulants or antiplatelets) please let us know beforehand, as these will need to be stopped a certain length of time before the procedure.
  • Examples include: warfarin, dalteparin, enoxaparin, tinzaparin, dabigatran, rivaroxaban, apixaban, clopidogrel, ticagrelor.
  • Low dose aspirin (75mg) is safe to continue.
  • Please discuss with a doctor before stopping any medicines, as sometimes other treatment will need to be given.
• If you have previously reacted to intravenous contrast medium (the dye used for CT scans), you must also tell your doctor about this.

What happens during the procedure?

• You will get dressed into a hospital gown.
• You will lie on the x-ray table, generally flat on your back.
• You will have a monitoring device attached to your finger, and will have a blood pressure cuff placed around your arm.
• The procedure is performed under sterile conditions and the radiologist and scrub nurse will wear sterile theatre gowns and operating gloves.
• Your skin will be cleaned and local anaesthetic given to numb the area, and prevent any pain. A small tube is then placed into the veins in your liver through your abdomen.
• Sometimes a further access site into the veins in your neck may be required.
• Small catheters (plastic tubes) will then be guided into the veins that are being investigated.
• When pictures need to be taken some iodine dye will be injected; you will be asked to hold your breath for a short time at these points. You may feel a hot feeling from the dye, and it can make your bladder feel full.
• Glue or a small device will then be used to block off the blood supply to the veins.
• Once the procedure is completed you will be moved back onto your hospital bed.
• The tube in the vein will then be removed, and pressure applied on the site for several minutes.

Will the procedure hurt?

• Some discomfort may be felt in the skin and deeper tissues during injection of the local anaesthetic.
• When the catheter is placed in the liver, you may get a dull ache in the right shoulder. This will disappear once the tube is removed.
• You may feel a warm sensation for a few seconds when the x-ray dye is injected and some people report a metallic taste in the mouth. You may also feel like you are passing urine; this is normal.
• There will be a nurse, or another member of the clinical staff, in the room looking after you.
• Following the procedure you may develop some abdominal or shoulder pain although this is unlikely. If you experience any of these symptoms, please let the nursing staff know.

How long does the procedure take?

Every patient’s situation is different, and it is not always easy to predict how complex or how straightforward the procedure will be. Generally, the procedure will last approximately 1-2 hours.

What happens after the procedure?

• You will be taken back to your ward for observations and a period of bed rest. You may also stay for further treatment or investigations.
• Nursing staff will carry out routine observations including taking your pulse and blood pressure readings and will also check the treatment site.
• If you experience pain, sickness, abnormal swellings or are generally feeling unwell, please let the nursing staff know.
• You will need to stay in bed for a few hours, until you have recovered.
• You may need to stay in hospital overnight.

What are the benefits and possible risks of the procedure?

Benefits

• The PVE/HVE is needed to assist with your liver surgery. It will help to ensure that there is a larger amount of normal liver post-surgery.

Risks

PVE/HVE is a safe procedure but as with any medical procedures there are some risks and complications.

• The main risk is inadvertent blockage of one of the other veins within the liver instead of the intended target. This occurs very rarely (1-2%). If this happens an emergency operation may be required to remove the blockage.
• There may be some bleeding and mild discomfort afterwards
• There is a chance of infection following the procedure.
• There is a chance that despite the procedure the remaining normal liver is still of an insufficient size required prior to surgery. In this situation your Consultant will discuss other options with you.

Radiation

• You have been referred for an Interventional Radiology procedure to help deliver your treatment. A specialist in radiology agrees that this is the best procedure to treat your clinical condition and that the benefit of the examination is greater than the risk.
• The x-ray involves a dose of ionising radiation equivalent to a few months or years of natural background radiation which we are all exposed to every day.
• Ionising radiation can cause cell damage that may turn cancerous, however the risk of this happening from your examination is considered low.
• Depending on the length of the procedure there may also be a small risk of an excess radiation dose to the skin leading to short term and long-term effects (e.g. reddening of the skin and burns).
• If this happens as a result of this procedure, you will receive further advice following the procedure. The dose delivered will be kept as low as is practicable.
• For further information please see the information on our webpage.

Accessibility requirements

If you require support for your appointment, e.g. if you find it hard to hear, see or be understood by others, please let the receptionist or healthcare professional know on arrival or

• Contact us by email

or

• Telephone: 01223 256998

Pregnancy status

We have a legal responsibility to enquire if you are pregnant. Any patient aged between 12-55 years will be asked if there is a possibility they could be pregnant. This is important for us to know before you have your examination involving ionising radiation.

You can discuss this with a healthcare professional in private if you wish.

Medication

Bring all of your medicines (including inhalers, injections, creams, eye drops or patches) and a current repeat prescription from your GP.

Can I bring someone with me?

Those accompanying you may be required to stay out of the examination room during the procedure and remain in the waiting area.

Childcare whilst in the department

Staff are unable to look after or supervise children whilst your procedure is taking place. Please make alternative arrangements for the care of your children whilst you attend for your procedure. If you attend an appointment with children with no one to look after them whilst you have your procedure, then your appointment will unfortunately have to be cancelled and rescheduled.

Personal belongings

Patients are advised to bring minimal belongings and not to bring valuable items. Any valuable belongings (mobile phone, wallet etc.) will go with the patient while having their procedure and can be secured in a locked box/safe.

How, when and by whom will my results be communicated?

Imaging examinations are reported in order of clinical priority to ensure those with the highest urgency are reported first.

Your referring team or clinician will be responsible for communicating reports back to you.

Test results are made available via MyChart but there is 3-week delay from when an examination has been reported to when it is available on MyChart, in order to allow time for your clinical team to be able to see and action the results prior to them being released to the individual patient.

Contacts/Further information

Please call the Radiology Day Unit and speak to the Imaging Nurses, on telephone number 01223 254639 if you have any questions or concerns about this procedure.

Some of your questions about the procedure should have been answered by this leaflet, but remember this is only a starting point for discussion about your treatment with the doctors looking after you and you will be able to discuss any questions you have with them.

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Question, concern or complaint?

Firstly speak to your nurse, doctor or other staff member as soon as you can so they can do their best to put things right straightaway.

If you don’t feel able to speak directly to the people caring for you, contact the patient advice and liaison service (PALS). Please call 01223 216756 9am to 4pm Monday to Friday, via email, or via a form available via link on the CUH PALS webpage.

PALS is open every weekday, and you can leave a message in the evenings and weekends.

MyChart

We would encourage you to sign up for MyChart. This is the electronic patient portal at Cambridge University Hospitals that enables patients to securely access parts of their health record held within the hospital’s electronic patient record system (Epic). It is available via your home computer or mobile device.

More information is available on our website: Mychart

This document has been adapted from one prepared by the British Society of Interventional Radiology (BSIR).