The Familial Gastric Cancer Study was set up in 1997 by Professor Carlos Caldas originally to collect information and blood samples from families with clustered cases of gastric cancer in the UK. Individuals who wish to participate in the Familial Gastric Cancer Study must fulfil the criteria for HDGC and provide their written consent. Additional information will be collected about the family history of cancer and pathology confirmations. With consent, we will try to confirm cancers in deceased members of the family, although this is usually done by the referring Genetic centre.
Departments / Units / service enhancers
Sue Richardson - Research nurse
A blood sample or saliva sample (which can be taken at home) will be collected which is stored for DNA analysis for our research. The relevant kit and envelope for return will be sent in the post to be returned to the Research Nurse in Cambridge. Your GP will also be contacted to inform them of your participation in the study. A few people taking part in the study will have an alteration (mutation) in a gene called CDH-1and the research team would like to collect more information about this. Individuals from families who meet the criteria for Hereditary Diffuse Gastric Cancer and who have undergone clinical testing will be invited to take part in the second part of the study called the “Hereditary Diffuse Gastric Cancer Registry”. If consent is given information will be held on the data register which is maintained here in Cambridge. Quality of Life questionnaires will be sent to the individual at regular intervals e.g. following genetic testing, endoscopic screening and before/after surgery. These questions help us to measure the impact of screening and surgery including morbidity, quality of life and the psychological effects of surgery.
Referrals to the study can be made in the first instance by contacting the Research Nurse. Clinicians who have identified patients will need to contact the Research Nurse. A permission slip can be given to the patient to sign which will allow the research team in Cambridge to contact them to provide further information about the study. Individuals may also contact the Research Nurse directly for more information either by telephone or email.