Familial cancer guidelines

Approximately 1 in 20 people in the United Kingdom develop colorectal cancer (CRC). Five to 10% of CRCs are due to an underlying genetic condition. The two most common genetic conditions associated with a significantly increased risk of CRC are familial adenomatous polyposis (FAP) and Lynch syndrome (hereditary non polyposis colonic cancer, HNPCC).

In FAP the risk of CRC is up to 100% and in Lynch syndrome the risk is up to 80%. Identification of those with these two conditions allows cost effective screening and a reduction in cancer related morbidity and mortality.

There are also a number of rare conditions and genes leading to a moderately increased risk of CRC for which it may be possible to offer genetic testing and/ or additional screening.

For more information download the guidelines below.