Dr Stephen Middleton
Consultant Gastroenterologist and Associate Lecturer, Cambridge University Hospitals.


01223 216 226
Mrs Tina Harris
GMC number: 
  • Functional bowel disorders (irritable bowel syndrome, dyspepsia, and swallowing disorders, constipation and evacuatory disorders))
  • Intestinal and multi-visceral transplantation
  • Inflammatory bowel disease (ulcerative colitis and Crohn’s disease)

Dr Stephen Middleton qualified in 1984 and after basic training undertook research in Cambridge, with the departments of Gastroenterology and the University department of Pharmacology in 1990. He identified the key missing neurotransmitter in Hirschsprung’s disease, the role of Nitric oxide in ulcerative colitis, and the mechanism regulating basal smooth muscle tone in the large intestine.  More recently he has described the condition of  “idiopathic accelerated gastric” which now has the eponymous name “Middleton Syndrome”.  

He has a particular interest in functional bowel disorders, dysphagia and oesophageal reflux and is the director of the “Gastrointestinal Physiology Unit” and the “Cambridge Irritiable Bowel Service”. He has been involved with the small bowel and multi-visceral  transplantation programme at Addenbrooke’s since it began in the early 90’s,  and has been the medical lead since 1995.  Addenbrooke’s is the only adult centre in the UK that undertakes both these procedures and over the last decade Cambridge has developed one of the largest and most successful  programmes in the world.  

His national contributions include co-founder and co-chair of the National Adult Small Intestinal Transplantation Forum (NASIT)  which has been adopted as the national listing meeting for all UK patients, chair of the BSG transplant research sub-committee, member of the national small bowel transplant advisory board, BSG clinical services and standards committee and  BSG small bowel and nutrition committee.  

Dr Middleton has delivered numerous international lectures including a discourse in the Faraday lecture series at the Royal Institute, London. He has over 60 peer reviewed publications, several book chapters and is UK chief investigator for several international studies on Inflammatory bowel disease and intestinal transplantation.