Consultant ENT Surgeon, MB BS, MA, PhD, FRCS (ORL- HNS)

Mr James Tysome, Consultant ENT Surgeon

GMC number: 4716723

Professional bodies:

  • Fellow of Royal College of Surgeons of England
  • ENT UK
  • British Society of Otology
  • British Skull Base Society
  • European Association of Otology and Neuro-otology

Clinical excellence award grade: Level 1


  • Otology
  • Hearing implants
  • Balance
  • Skull Base surgery

Mr Tysome is a Consultant ENT surgeon with specialist interests in ear surgery, cochlear implants and skull base surgery in both adults and children. He is clinical lead of the regional skull base unit and a member of the hearing implant, head and neck, neurofibromatosis type 2 and pituitary multidisciplinary teams, providing high quality specialist care. He is an advisory member of Cambridge University Health Partners Innovation Hub and National Health Institute for Research Eastern region deputy lead for ENT.

He read medicine at Cambridge University and University College London. His ENT training took place in the London region. He undertook Skull Base Fellowships in Cambridge and Stanford University in California, USA, before taking up his consultant post in 2012.

Mr Tysome has a PhD in molecular biology and his current research programme investigates Eustachian tube dysfunction, novel therapies for vestibular schwannomas and outcome measures in hearing implants, supervising MPhil and PhD students. He is an Associate Editor of Clinical Otolaryngology, has published over 40 papers, presents his work internationally and has edited three books; "Dizziness and Vertigo" was highly commended in the British Medical Association awards 2015. His academic prizes include the Royal Society of Medicine FRCS(ORL-HNS) gold medal.

Papers and publications:

  1. Smith ME, Tysome JR Tests of Eustachian Tube Function: A Review.Clin Otolaryngol. 2015 Apr 8. [Epub ahead of print]
  2. Taylor RR, Jagger DJ, Saeed SR, Axon P, Donnelly N, Tysome J, Moffatt D, Irving R, Monksfield P, Coulson C, Freeman SR, Lloyd SK, Forge A. Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. Neurobiol Aging. 2015 Jun;36(6):2068-84
  3. Martin TP, Moualed D, Paul A, Ronan N, Tysome JR, Donnelly NP, Cook R, Axon PR. The Cambridge Otology Quality of Life Questionnaire: an otology-specific patient-recorded outcome measure. A paper describing the instrument design and a report of preliminary reliability and validity. Clin Otolaryngol. 2015 Apr;40(2):130-9.
  4. Broomfield SJ, Murphy J, Wild DC, Emmett SR, O'Donoghue GM; Aleksy W, Axon PR, Banerjee A, Bele D, Bowcott S, Bruce IA, Cochrane LA, Cooper S, Daft M, Donnelly N, Fitzgerald O'Connor A, Freeman SR, Gray RF, Green KM, Hajioff DA, Hanvey K, Harris R, Hartley BE, Hartley D, Hatton N, Hawthorne MH, Hellier W, Humphries J, Irving R, Jiang D, Jephson CG, Jonas NE, Jones L, Khan IM, Lavy JA, Lloyd SK, Maddocks J, Maggs JK, Marshall AH, Martin JM, Millward K, Mitchell T, Morrison G, Patel S, Pringle M, Raine CH, Rajput KM, Ramsden JD, Ramsden RT, Reid AP, Robinson PJ, Saeed SR, Selvadurai D, Shaida A, Speers A, Strachan DR, Toner JG, Tysome JR, Tzifa K, Twomey T, Wheeler A, Wilson K, Wyatt ME. Results of a prospective surgical audit of bilateral paediatric cochlear implantation in the UK. Cochlear Implants Int. 2014;15(5):246-53
  5. Masterson L, Moualed D, Liu ZW, Howard JE, Dwivedi RC, Tysome JR, Benson R, Sterling JC, Sudhoff H, Jani P, Goon PK. De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis of current clinical trials. Eur J Cancer. 2014;50(15):2636-2648
  6. Walton J, Donnelly NP, Tam YC, Joubert I, Durie-Gair J, Jackson C, Mannion RA, Tysome JR, Axon PR, Scoffings DJ. MRI without magnet removal in neurofibromatosis type 2 patients with cochlear and auditory brainstem implants. Otol Neurotol. 2014 Jun;35(5):821-5.
  7. Masterson L, Rouhani M, Donnelly NP, Tysome JR, Patel P, Jefferies SJ, Roques T, Scrase C, Mannion R, Macfarlane R, Hardy D, Durrani A, Price R, Marker A, Axon P, Moffat DA. Squamous cell carcinoma of the temporal bone: clinical outcomes from radical surgery and postoperative radiotherapy. Otol Neurotol. 2014;35(3):501-8.
  8. Murillo-Sauca O, Chung MK, Shin JH, Karamboulas C, Kwok S, Jung YH, Oakley R, Tysome JR, Farnebo LO, Kaplan MJ, Sirjani D, Divi V, Holsinger FC, Tomeh C, Nichols A, Le QT, Colevas AD, Kong CS, Uppaluri R, Lewis JS Jr, Ailles LE, Sunwoo JB. CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma. Oncotarget. 2014;5(16):6854-66
  9. Tysome JR, Lemoine NR, Wang Y.  Update on oncolytic viral therapy - targeting angiogenesis. Onco Targets Ther. 2013 Jul 31;6:1031-40
  10. Tysome JR, Axon PR, Donnelly NP, Evans DG, Ferner RE, O'Connor AF, Freeman SR, Gleeson M, Halliday D, Harris F, Jiang D, Kerr R, King A, Knight RD, Lloyd SK, Macfarlane R, Mannion R, Mawman D, O'Driscoll M, Parry A, Ramsden J, Ramsden R, Rutherford SA, Saeed SR, Thomas N, Vanat ZH. English consensus protocol evaluating candidacy for auditory brainstem and cochlear implantation in neurofibromatosis type 2. Otol Neurotol. 2013 Dec;34(9):1743-7
  11. Hiley C, Chard L, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y. Vascular Endothelial growth factor-A promotes vaccinia virus entry into host cells via activation of the Akt pathway. J Virology 2013;87(5):2781-90
  12. Moffat DA, Lloyd SK, Macfarlane R, Mannion R, King A, Rutherford S, Axon PR, Donnelly N, Freeman S, Tysome JR, Evans DG, Ramsden RT. Outcome of translabyrinthine surgery for vestibular schwannoma in neurofibromatosis type 2. Br J Neurosurg. 2013;27(4):446-53.
  13. Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R, Chard L, Yuan M, Alusi G, Lemoine NR, Wang Y. A novel therapeutic regime to eradicate established solid tumors with an effective induction of tumor-specific immunity. Clin Cancer Res 2012;18(24):6679-89
  14. Tysome JR, Macfarlane R, Durie-Gair J, Donnelly N, Mannion R, Knight R, Harris F, Vanat ZH, Tam YC, Burton K, Hensiek A, Raymond FL, Moffat DA, Axon PR. Surgical management of vestibular schwannomas and hearing rehabilitation in neurofibromatosis type 2. Otology Neurotology 2012;33(3):466-72
  15. Tysome JR, Moffat DA. Magnetic Resonance Imaging following translabyrinthine complete resection of vestibular schwannomas. J Neurol Surg B 2012;2:121-124
  16. Connor SE, Siddiqui A, O'Gorman R, Tysome JR, Lee A, Jiang D, Fitzgerald-O'Connor A. Magnetic resonance imaging features of large endolymphatic sac compartments: audiological and clinical correlates. J Laryngol Otol 2012 ;126(6):586-93
  17. Mahrous AK, Tysome JR, Davis JP.  A prospective randomised controlled trial in one hundred and eleven patients to determine whether flexible nasendoscopic laryngoscopy is more comfortable for patients when performed above or below the inferior turbinate. Clin Otolaryngol 2012;37(3):238-40
  18. Simo R, Nixon I, Tysome JR, Balfour A, Jeannon JP. Modified extended Kocher incision for total thyroidectomy with lateral compartment neck dissection - a critical appraisal of surgical access and cosmesis in 31 patients. Clin Otolaryngol. 2012 Oct;37(5):395-8
  19. Tysome JR, Wang P, Briat  A,  Alusi G, Gangeswaran R, Bhakta V, Francis J, Timiryasova T, Fodor I, Lemoine NR, Wang Y. Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: a superior oncolytic virus to dl1520 (ONYX-015) for human head and neck cancer. Human Gene Therapy 2011;22(9):1101-8
  20. Tysome JR, Moorthy R, Lee AD, Jiang D, Fitzgerald O’Connor AF. Systematic review of middle ear implants: do they improve hearing as much as conventional hearing aids? Otology Neurotology 2010;31(9):1369-75
  21. Lee A, Jiang D, McLaren S, Nunn T, Delmer J, Tysome JR, Connor S, Fitzgerald O’Connor A. Electric Acoustic Stimulation (EAS) of the Auditory System: Experience and Results of Ten Patients Using MED-EL’s M and FlexEAS Electrodes. Clin Otolaryngol 2010;35(3):190-7
  22. Elliott MS, Odell, EW, Tysome JR, Connor SEJ, Siddiqui A, Jeannon JP, Simo R. Role of thyroidectomy in advanced laryngeal and pharyngolaryngeal carcinoma. Otolaryngol Head Neck Surg 2010;142(6):851-5
  23. Tysome JR, Jeannon JP, Simo R. Hydrogen peroxide aids assessment of pharyngeal closure after laryngectomy. J Laryngol Otol 2010;124(2):205-6
  24. Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S, Dong S, Wang S, Deng L, Francis J, Timiryasova T, Fodor I, Lemoine NR, Wang Y. Lister vaccine strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic carcinoma. Gene Therapy 2009;16(10):1223-33
  25. Tysome JR, Lemoine N, Wang Y. Combining anti-angiogenic therapy and virotherapy. Curr Opin Mol Ther 2009; 11(6):664-9
  26. Tysome JR, Chandra A, Chang F, Puwanarajah P, Elliott M, Caroll P, Powrie J, Hubbard JG, Clarke SEM, Jeannon JP, Simo R. Improving prediction of malignancy of cytologically indeterminate thyroid nodules. Brit J Surg 2009; 96(12):1400-9
  27. Tysome JR, Hassan R, Davis JP. Standard bipolar diathermy vessel ligation for thyroidectomy. Eur Arch Otorhinolaryngol 2009; 266(11):1781-6
  28. Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome JR, Bhakta V, Yuan M, Chikkanna-Gowda CP, Jiang G, Gao D, Cao F, Francis J, Yu J, Liu K, Yang H, Zhang Y, Zang W, Chelala C, Dong Z, Lemoine N.CEACAM6 attenuates the ability of adenovirus to infect cancer cells by blocking Src-mediated viral trafficking. J Clin Invest 2009;119(6):1604-15
  29. Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L. Aggressive Papillary Tumor of the Middle Ear: a True Entity or an Endolymphatic Sac neoplasm? Ear Nose Throat J 2008;87(7):378-93 
  30. Dexter S, Haiashi D, Tysome JR. The ANKLe score: an audit of otolaryngology emergency clinic record keeping. Annals R Coll Surg 2008;90(3):231-4
  31. Haiashi D, Tysome JR, Barbaccia C. Sebaceous lymphadenoma of the parotid gland: report of two cases and review of the literature Acta Otorhinolaryngol Italia 2007; 27 (3):144-6
  32. Tysome JR, Saleh HA. Sphenochoanal polyps presenting with concomitant nasal polyps. Ear Nose Throat J 2007: 86:50-52
  33. Tysome JR, Henry RC. Silver nitrate suction diathermy. Clin Otolaryngol 2007;32:25
  34. Tysome JR, Henry RC. Nasal catheter insertion for suction diathermy adenoidectomy – response to Whitehead. Clin Otolaryngol 2006;31:458
  35. Tysome JR, Padgham ND. A comparative study of patient satisfaction with day case and inpatient major ear surgery. J Laryngol Otol 2006;120:670-5
  36. Tysome JR, Henry RC. Nasal catheter insertion for suction diathermy adenoidectomy. Clin Otolaryngol 2006:31;237-8
  37. Tysome JR, Sandison A, Clarke PM. Liposarcoma metastatic to the thyroid gland: a case report and literature review. J Laryngol Otol 2006;120:511-3
  38. Tysome JR, Sharp HR. Current trends in the pre and postoperative management of functional endoscopic sinus surgery. Int J Otorhinolaryngol 2006;5:2
  39. Tysome JR, Sharp HR. Current trends in photographic imaging for rhinoplasty surgery. Int J Otorhinolaryngol 2006;5:2
  40. Tysome JR, Kangalingham J, Grant WE. Episodic painful oculomotor palsy from an orbital metastasis of oesophageal adenocarinoma. Int J Otorhinolaryngol 2006:4(2)
  41. Tysome JR, Harcourt J. How we do it: ionomeric cement to attach the stapes prosthesis to the long process of the incus. Clin Otolaryngol 2005:30;458-60
  42. Gnanalingham KK, Tysome JR, Martinez-Canca J and Barazi B.  Quality of clinical studies in Neurosurgical journal: Signs of improvement over three decades? J Neurosurgery 2005;103:439-44
  43. Jiao LR, Tysome JR, Navarra G and Habib N. Liver resection in a patient with concomitant thoracoabdominal and cerebral aneurysms. Hepatopancreatobil Surg 2005;7:73-76
  44. Tysome JR, Gnanalingham KK, Chopra I and Mendoza N. Intradural  metastatic spinal cord compression from ACTH-secreting Pituitary  Carcinoma – Case report and literature review. Acta Neurochirurgica (Wien) 2004;146:1251-4
  45. Wales L, Tysome J, Lim A, Moser S, Tait P, Navarra G. Images of interest - Gastrointestinal: Caecal Volvulus. J Gastroenterol Hepatol 2004;19:225. 
  46. Wales L, Tysome J, Menon R, Habib N, Navarra G. Caecal volvulus following laparoscopy-assisted sigmoid colectomy for sigmoid volvulus. Int J Colorectal Dis 2003;18:529-532.
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