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East of England Immunoglobulin Assessment Panel (EoE IAP)

The East of England Immunoglobulin Assessment Panel (EoEIAP) is hosted by Cambridge University Hospitals. All treatment with immunoglobulins is subject to review or authorisation by the Panel.

Trusts signed up to oversight by the EoEIAP
  • Bedfordshire Hospitals NHS Trust
    • Including Bedford Hospital
    • Excluding Luton & Dunstable Hospital
  • Cambridge University Hospitals NHS Foundation Trust
  • East and North Hertfordshire NHS Trust
  • East Suffolk and North East Essex NHS Foundation Trust, incorporating the former
    • Colchester Hospital University NHS Foundation Trust
    • Ipswich Hospital NHS Trust
  • James Paget University Hospitals NHS Foundation Trust
  • Mid and South Essex NHS Foundation Trust, incorporating the former
    • Basildon and Thurrock University Hospitals NHS Foundation Trust
    • Mid Essex Hospital Services NHS Trust
    • Southend University Hospital NHS Foundation Trust
  • Norfolk and Norwich University Hospitals NHS Foundation Trust
  • North West Anglia NHS Foundation Trust
  • Princess Alexandra Hospital NHS Trust
  • Queen Elizabeth’s Hospital King’s Lynn
  • Royal Papworth Hospital NHS Foundation Trust
  • West Suffolk Hospital NHS Foundation Trusts

Latest news and updates

November 2021

Previous news

July 2021

New 18 month NHS Framework launched. Significant shortages globally of immunoglobulins that will affect the NHS. Mitigation plans in preparation.

April 2021

Update to clinical guidelines for the following conditions: Treatment of measles and Covid-vaccine associated thrombosis and thrombocytopenia

March 2021

All Trusts must now notify the EOEIAP of all immunoglobulin use either for approval or retrospectively for Class 1

February 2021

UK Plasma now sanctioned for the manufacture of immunoglobulins

Clinical requests

Applications for treatment with immunoglobulins require a completed Immunoglobulin Clinical Approval Request Form prior to treatment (± funding authorisation by IFR, depending on the condition to be treated). Download and complete the form (below) and submit to the EoE IAP for panel consideration.

All requests for immunoglobulin replacement therapy (in primary or secondary immunodeficiency) should be made using the following form:

All clinical requests to authorisation to the panel should be made to:

All authorised treatment requests require the treating consultant to review the patient’s clinical response in accordance with the specified clinical measures for the indication, or as specified by the panel at the point of approval to treat.

Patients should be informed that panel approval is required before treatment can begin for any Class II-V indications (Class I indications may proceed within defined limits without panel approval).

As part of the process of consent to treatment, patients with capacity should be given a copy of the Immunoglobulin Patient Information Leaflet (below) prior to treatment, along with the opportunity to read and ask questions about treatment before treatment proceeds.

Clinical guidelines

The regional (EOE) immunoglobulin treatment guidelines combine the latest guidelines as published by NHS England and the Department of Health, as well as regional standards as specified by the EoE IAP. Local standards include further detail on the approvals required per indication, permission to treat out of hours and the agreed dosing strategies for indications that previously have not been covered by particular guidance. This guidance should be used as the primary reference source by NHS providers in the East of England, and in preference to other documents including those published by commissioners.

Associate Trusts of the EoE IAP agree to adhere to the standards specified by the EoE IAP and to accept the decisions of the EoE IAP as binding. This stance is supported by the medical directors of the Trusts in the East of England.

A pathway exists for a second opinion to be sought from an associate SRIAP (sub-regional IAP). Where the EoE IAP has declined to support treatment with immunoglobulins, please contact directly to request a clinical review by an associate SRIAP. Do not submit patient identifiable data to this email address, unless using an email account OR by writing [secure] in the title of an email to ensure the message is encrypted.

Submission of data to the East of England IAP

The following email distribution list should be used for the submission of purchasing data, allocation change requests and other communications of a general nature that do not involve clinical decision making or data that is patient-confidential

Regional allocations are monitored by the IAP and a summary of the set allocations can be requested from the regional IVIG coordinator

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