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Professor John Benson
Consultant Breast Surgeon

MA DM (Oxon) MD (Cantab) FRCS (Eng) FRCS (Ed)

 

Professor John  Benson is a Consultant Breast Surgeon in the Cambridge Breast Unit at Addenbrooke’s Hospital, Cambridge, UK. He received his basic medical degree from Oxford University Clinical School and has been awarded doctorates from both Oxford and Cambridge Universities [DM (Oxon); MD (Cantab)].  He was a research fellow at The Royal Marsden Hospital and Institute of Cancer Research, London and undertook internships both at the Royal Marsden Hospital in Surrey and the Chelsea and Westminster Hospital, London, UK. Further experience was gained in management of breast diseases as Visiting Professor at the New York Hospital - Cornell Medical Centre. Professor Benson is a Fellow of Selwyn College, Cambridge where he is also Director of Clinical Studies, Associate Lecturer, University of Cambridge and Professor of Applied Surgical Sciences at Anglia Ruskin University, Cambridge, UK. He is a member of the Panel of Examiners, Intercollegiate MRCS Examination (Royal College of Surgeons of Edinburgh) and was appointed a Regional Breast Tutor by The Royal College of Surgeons of England.  He is a Fellow of the Royal College of Surgeons of England, a Fellow of the Royal College of Surgeons of Edinburgh and a member of the British Breast Group. His clinical practice is devoted entirely to patients with breast diseases and current research interests include investigation of a fluorescent navigation system for sentinel lymph node detection in early breast cancer patients. He has published three papers in the past 3 years on this topic – all in American journals and one of these a leading commentary summarizing where we are and where we are going with this technology (Annal of Surgical Oncology). Professor Benson is principle investigator for two national breast cancer trials (POSNOC and MarginProbe) and regularly acts as reviewer for major grant giving bodies (Cancer Research UK, Medical Research Council, Breast Cancer Now and NIHR). 

Professor Benson has published widely in the field of breast disease in general (>140 publications) and co-ordinated or written articles for leading journals including The Lancet and The Lancet Oncology, Annals of Surgery, British Journal of Surgery, Surgical Clinics of North America and Breast Diseases Quarterly. He has also contributed numerous book chapters and presented papers at major international meetings. He is author and editorial consultant for the breast module of PIER (American College of Physicians) and a Module Lead for the Masters in Oncoplastic Breast Surgery (E-Learning) (Royal College of Surgeons of England and University of East Anglia) [Gold Award for e-learning 2013]. In addition, he is co-editing the third edition of the text “Oncoplastic and Reconstructive Management of the Breast” with colleagues from the United States and Italy and this should be ready for publication in early 2018.

Over the past 3 years Professor Benson has undertaken invited speaker presentations in the United States, Brazil, Japan, Kuwait, Italy and Spain. In September 2015, he visited the University of Pernambuco in Brazil (Faculdade de Ciencias Medicas) where he gave a memorial lecture to his former Professor and mentor who sadly died in July of last year. Antonio Figueira Filho was a pioneer of breast surgery in South America and inspired Professor Benson to pursue a career in this field following an attachment there exactly 30 years ago! He is a former member of the Planning Committee for the San Antonio Breast Cancer Symposium which is the world’s premier breast cancer meeting with >8000 attendees from 100 countries outside the United States of America.  This is a two year term which he completed in 2015 but continues to be closely involved with the symposium and has remained as a discussant for the Career Development Forum which is a popular component of the meeting. He was Visiting Professor at the University of Texas, Health Sciences Centre at San Antonio in December 2016 and had the honour of being invited to deliver the Grand Round Lecture (Department of Surgery). He was elected to the Executive Board of the Association of Breast Surgery (United Kingdom) as an Ordinary Trustee in September 2016 (receiving the highest number of votes amongst 8 applicants). He is currently co-convener for the Advanced Skills in Breast Disease Course at the Royal College of Surgeons of England. Professor Benson was invited to a Parliamentary Luncheon at the House of Commons in 2017 as part of a working group to discuss surgery for benign breast disease and lesions of uncertain malignant potential.

Publications from 2012 to present:

Benson JR   Diagnosis and local management of breast cancer: parts I and II (conference scene).  Future Oncol 2011; 7 (8): 959 – 961

Benson JR, Wishart GC. Axillary dissection for sentinel node positive patients with early stage breast cancer (leader article).  Br J Surg  2011; 98: 1499 – 1500

Benson JR.   Commentary on paper ‘Phase III randomized equivalence trial of early breast cancer treatments with or without clearance in post-menopausal patients: results after 5 years of follow up.’   Breast Diseases: A Year Book Quarterly (2011)

Benson JR.  Longer term outcomes of breast conservation therapy. Lancet Oncol 2012; 13(4): 331 – 333

Llewellyn-Bennet R, Greenwood R, Benson J, English R, Turner J, Rayter Z, Winters ZE.  A randomized controlled trial evaluating the effect of the fibrin sealant Tisseel on latissimus dorsi donor site seroma formation in breast breast reconstruction.  Br J Surg 2012; 99(10): 1381 - 1388

Wishart GC, Jones LC, S-W Loh, Benson JR.  A feasibility study (ICG-10) of indocyanine green for sentinel lymph node detection in early breast cancer. Eur J Surg Oncol 2012; 38: 651 - 656

Benson JR, Jatoi I.  The Global burden of breast cancer.  Future Oncol 2012; 8 (6): 697 – 702

Benson JR.  Management of breast cancer patients with sentinel lymph node micrometastases.   Lancet Oncol 2013; (March 11th) doi:10.1016/S1470-2045(13)70074-3

Jatoi I, Benson JR.  The role of pre-operative MRI in breast cancer patients.  Future Oncol 2013; 9(3): 347 – 53

Benson JR, Wishart GC.  Predictors of recurrence for ductal carcinoma in situ after breast conserving surgery.  Lancet Oncol 2013; 14 (9): e348 – 57 [doi: 10.1016/S1470-2045(13)70135-9]. (Interview and citation in article for Proto Magazine (Time Inc) 2014)

Wishart GC, Benson JR. Non-radioactive tracers in sentinel lymph node biopsy for early breast cancer.  Association of Breast Surgeons Newsletter (Summer 2013)

Winters ZE, Haviland J, Balta V, Benson J, Reece-Smith A, Betambeau N, et al. Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment. Br J Surg 2013; 100(2): 240-51

Benson JR, Wishart GC.   Ductal Carcinoma in Situ: A Clinical Conundrum.   Breast Diseases: A Year Book Quarterly  2013; 24: No. 4 1 – 3

Benson JR.  A Comparison of Indocyanine Green Fluorescence and blue dye for sentinel lymph node biopsy in early breast cancer.   Breast Diseases: A Year Book Quarterly.

Jatoi I, Benson JR.     SABCS  2014 Future Oncol 2014; 10(4): 515 – 518

Down SK, Lucas O, Wishart GC, Benson JR. The effect of PREDICT on chemotherapy/trastuzumab recommendations in HER2 positive patients with early-stage breast cancer. Oncol Letters 2014; 8 (6): 2757 - 2761

Benson JR, Jatoi I. Sentinel lymph node biopsy and neoadjuvant chemotherapy in breast cancer patients.   Future Oncology  2014; 10: (4) 577 - 586

Turner EJ, Benson JR, Winters ZE. Techniques in the prevention and management of seromas after breast surgery.   Future Oncology  2014; 10: (6) 1049 – 1063

Halsted, CP, Benson JR, Jatoi I.  A historical account of breast cancer surgery: beware of local recurrence but be not radical. Future Oncology  2014; 10: (9) 1649 – 1657

Toi M, Winer E, Benson JR, et al. Personalization of loco-regional care for primary breast cancer patients (Part 1).  Future Oncol 2015; 11(9): 1297 - 300  doi: 10.2217/fon.15.65

Toi M, Winer E, Benson JR, et al. Personalization of loco-regional care for primary breast cancer patients (Part 2).  Future Oncol 2015; 11(9): 1301 – 5  doi: 10.2217/fon.15.66

Benson JR. Conference Report (San Antonio Breast Cancer Symposium 2014)  Oncology News  2015; 10: (2) 45 - 47

Benson JR, Jatoi I.   Clinical strategies for chemoprevention of breast cancer (Part 1). Oncology News  2015; 10: (4) 97 – 100

Benson JR, Dumitru D, Malata CM.   Oncologic safety of conservative mastectomy in the therapeutic setting. Gland Surgery 2015 doi: 10.3978/j.issn.2227-684X.2015.05.13

Benson JR, Jatoi I.   Clinical strategies for chemoprevention of breast cancer (Part 2). Oncology News  2015; 10: (5) 121 – 123

Benson JR.  Indocyanine green fluorescence for sentinel lymph node detection in early breast cancer.  Annals Surg Oncol  2015;  DOI  10.1245/s10434-015-4801-z

Benson JR, Winters ZE.  Contralateral Prophylactic Mastectomy.  Br J Surg 2016; 103(10): 1249 – 1250

Benson JR, Jatoi I.  Highlights of the San Antonio Breast Cancer Symposium 2015 (Part 1).  Future Oncol 2016; 12(7); 893 – 896

Benson JR, Jatoi I.  Highlights of the San Antonio Breast Cancer Symposium 2015 (Part 2).  Future Oncol 2016; 12(7); 897 - 900

 Benson JR, Jatoi I, Toi M.  Treatment of low-risk ductal carcinoma-in-situ: is nothing better than something? Lancet Oncol 2016; 17(1): e442 – e451

Jatoi I, Benson JR, Toi M.  De-escalation of axillary surgery in early breast cancer. Lancet Oncol 2016; 17(10): e430 – e441

Benson JR, Down SK.   Oncoplastic surgery comes of age.  Br J Surg 2017;  (in press)

Books

“Early Breast Cancer - from screening to multidisciplinary management “  (Benson JR) [LEAD EDITOR], Tuttle T, Gui G, eds.) CRC Press Publishers, Florida, London, New York [ISBN 978-1-84184-885-3] (3rd Edition) (published January 2013 (First Prize in Oncology Section of BMA Medical Book Awards 2013)

Publications Late 2009 - Late 2011

Papers/articles

Benson JR. Will ductal carcinoma in situ defeat breast cancer screening? BMJ 2009; 338: 615 

Benson JR.  Managing the contralateral breast in a gene mutation carrier with breast cancer (FEATURE ARTICLE).  Advances in Breast Cancer ; March 2009  1 – 7

Benson JR and Liau S-S.  Cancer Genetics [COMMISSIONED ARTICLE].  Current Topics in Surgery 2010; 88: 681 – 704

Winter ZE, Benson JR, Pusic A.  A systematic review of the clinical evidence to guide treatment recommendations in breast reconstruction based on patient reported outcome measures and health related quality of life.

Ann Surg 2010; 252: 929 - 42  [IMPACT FACTOR 8.4] (collaborative publication with colleagues from the University of Bristol and Memorial Sloan-Kettering Cancer Centre, New York)

Benson JR.  An alternative to axillary lymph node dissection.
Lancet Oncol  2010; 11:908 - 909

Benson JR, Wishart GC. Is intra-operative nodal assessment essential in a modern breast practice? Eur J Surg Oncol  2010; 36: 1162 – 1164

Benson JR, Wishart GC. Is intra-operative nodal assessment essential in a modern breast practice? Response to correspondence. Eur J Surg Oncol  2011; 37: 453

Benson JR, Teo K.   Breast cancer local therapy: What is it’s effect on mortality? 
World J Surg 2011; (in press)

Benson JR. Diagnosis and local management of breast cancer: part II (conference scene). Future Oncol 2011; 7: 959-61

Benson JR. Diagnosis and local management of breast cancer: part I (conference scene). Future Oncol 2011; 7: 955-7

Benson JR, Wishart GC.   Axillary dissection for node positive patients with early stage breast cancer (leader article). Br J Surg  2011; doi:10.1002/bjs.7684

Winters ZE, Haviland J, Reece-Smith A, Betambeau N, Choudhry  K, Chaudhry A , Mills J , Benson JR , Galea M, MacMannus P, Nicholson S, Weiler-Mithoff E, Rayter Z, Thomson  H.  Multi-centre prospective cohort study evaluating the integration of Patient Reported Outcome Measures (PROMS) with key clinical outcomes after types of immediate Latissimus Dorsi (LD) breast reconstruction and the effects of post-mastectomy radiotherapy.  Br Med J (submitted August 2011)

Abstracts

Winters ZE, Mills J, Haviland J, Reece-Smith A, Greenslade M, Benson JR et al.   A Multicentre Prospective Longitudinal Study Establishing Level II Evidence of Health Related Quality of Life after Types of Immediate Latissimus Dorsi (LD) Breast Reconstruction.  Cancer Res 2009; 69: 682S

Benson JR, Wishart GC, Forouhi P, Provenzano E.  How often does a positive lymph node biopsy prompt an isolated delayed axillary lymph node dissection? Eur J Cancer 2010; 8: No. 6  28

Benson JR, Wishart GC, Ambler G, Provenzano E.  Sentinel lymph node biopsy before primary chemotherapy in breast cancer patients. Eur J Cancer 2010; 8: No. 6  29

Winters ZE, Mills J, Haviland J, Reece-Smith A, Greenslade M, Benson JR et al.   A Multicentre Prospective Longitudinal Study Evaluating Health Related Quality of Life after Immediate Latissimus Dorsi (LD) Breast Reconstruction.   Eur J Cancer 2010; 8: No. 6  34

Benson JR, Wishart GC, Forouhi P, Provenzano E.  How often does a positive lymph node biopsy prompt an isolated delayed axillary lymph node dissection? Cancer Res 2010; 70: 135S

Wishart GC, S-W Loh, P Britton, Benson JR.   Fluorescence mapping with indocyanine green (ICG) for sentinel lymph node detection in early breast cancer. Eur J Surg Oncol 2011; 32: S4

Winters ZE, Chaudhry A, Massey E, Benson JR.  A systematic review of patient reported outcome measures (PROMS) and clinical outcome reporting in breast reconstruction. Eur J Surg Oncol 2011; 32: S16

Books

“Management Options in Breast Cancer – case histories, best practice and clinical decision-making” Benson JR, Jatoi I.  Informa Healthcare, New York [ISBN -10:0-415-42310-4]. (2009)

“Oncoplastic and Reconstructive Surgery of the  Breast  (Querci della Rovere G, Benson JR and Nava M Eds)  Informa Healthcare [ISBN 9780415477284] (published December 2010)

Publications 2007 - 2009

Articles

Benson JR and Querci della Rovere G.  Management of the axilla in women with breast cancer.  Commissioned review article incorporating collective viewpoints from local opinion leaders in the UK, USA, Europe and Australasia  Lancet Oncology 2007;  8:  331 – 348

Benson JR and Ravisekar O.  Aromatase inhibitors in the treatment of breast cancer.  Comissioned article for Current Cancer Treatment Reviews 2007;  3:  67 – 79

Benson JR.   Breast cancer and novel therapeutic treatments (GUEST EDITORIAL). European Oncological Disease 2007;  Issue 1 22 – 26

Querci della Rovere G, Biswas N, El-Zayat A, Benson JR.   Technical modifications of the “Grisotti” advancement-rotation flap.   Indian J Surg 2007; 69: 160 - 162

Querci della Rovere G, Nava M, Bonomi R, Catanuto G and Benson JR.  Skin reducing mastectomy with breast reconstruction and sub-pectoral implants.  accepted J Plast Reconstr Aesthetic Surg 2008; 61: 1303 - 1308

Querci della Rovere G and Benson JR.  Management of the axilla in women with breast cancer.  Breast  2007; 16: 130 - 136

Benson JR and Querci della Rovere G.  Ipsilateral breast tumour recurrence. Breast  2008;  17:  12 – 18

Benson JR.   Ovarian ablation as non-surgical treatment for breast cancer. Lancet Oncology 2008;  9: 80

Benson JR and Shamim Absar M.  Volume replacement and displacement techniques in oncoplastic surgery.   Advances in Breast Cancer 2008 (March); 1 - 8

Benson JR and Liau S-S.  Cancer Genetics: A primer for surgeons. Surgical Clinics of North America 2008;  88:  681 – 704

Coles CE, CB Wilson, Cumming J, Benson JR, Forouhi P, Wilkinson JS, Rena R, Wishart GC. Titanium clip placement to allow accurate tumour bed localization following breast conserving surgery – audit on behalf of the IMPORT Trial Management Group.   Eu J Surg Oncol  e-pub 2008

Britton PD, Goud A, Godward S, Barter S, Freeman A, Gaskarth M, Rajan P, Sinnatamby R, Slattery J, Provenzano E, O’Donovan M, Pinder S, Benson JR, Forouhi P, Wishart GC. Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer. Eur Radiol 2008; DO1  10.1007/s00330-008-1177-5

Britton PD, Provenzano E, Barter S, Gaskarth M, Goud A, Moyle P, Sinnatamby R, Wallis M, Benson JR, Forouhi PF, Wishart GC.  Ultrasound-guided percutaneous axillary lymph node core biopsy: how often is the sentinel lymph node being biopsied?   The Breast (epub November 2008)

Benson JR, Jatoi I, Keisch M, Esteva FJ, Makris A, Jordon VC.   Early Breast Cancer.   Lancet 2009; 373: 1463 - 1479

Books

Benson JR, Jatoi I.  ‘Management Options in Breast Cancer - Case histories, Best Practice and Clinical Decision-Making.’   Informa Healthcare, New York [for publication March 2009]

Book chapters

Benson JR.   Chapter entitled “Breast” in “Essential Surgery”  (Burkitt HG and Quick CRG  Eds)  Churchill Livingston Publishers  (4th Edition) 2008

Benson JR.   Chapter entitled “Breast” in “Applied Basic Science for Basic Surgical Training”  (Andrew T. Raftery Ed)  Churchill Livingston Publishers  (2nd Edition) (for publication 2008)

Benson JR and Liau SS.  Chapter entitled “The Nature and Development of Cancer” in “The Oxford Textbook of Medicine”  (T Cox T Editor)  Oxford University Press Publishers  (New Edition) (for publication 2009)

Benson JR, Turner EH, Winters ZE. Chapter entitled “Side effect of Tamoxifen and Anastrozole” in “Methods of Cancer Diagnosis, Therapy and Prognosis”  (Hayat MA Ed)   Springer Company Publishers  (1st Edition) (for publication 2009)

Benson JR, Pitsinis V.  Chapter entitled “Management of the axilla” in “Manual of Breast Diseases” (Jatoi I Ed) Lippincott Williams & Wilkins Publishers (2nd Edition)  (in preparation)

Publications (pre 2007)

Articles

Benson JR. Will ductal carcinoma in situ defeat breast cancer screening? BMJ 2009;  338: 957

Benson JR and Baum M.  Breast cancer, desmoid tumours and Familial Adenomatous Polyposis - a unifying hypothesis.  Lancet   1993;  342:   848 - 850

Benson JR and Baum M.  Transforming growth factor ß isoforms in breast cancer. Br J Cancer   1994;   70:  1278

Colletta AA, Benson JR and Baum M. Alternate mechanisms of action of antioestrogens. Breast Cancer Research and Treatment  1994;  31:  5 - 9  

Benson JR Baum M and Colletta AA.   Stromal - Epithelial Interactions in Carcinogenesis.    Cancer Topics   1996;  10: No.5   10 - 12

Benson JR Transforming growth factor ß: Prospects for Cancer Prevention and Treatment. [Leading Article]  Clinical Immunotherapeutics   1995;  4:  No.4   249 - 258

Benson JR and Wells K.  Microsatellite instability and a TGFß receptor - clues to a growth control pathway.   BioEssays   1995;  17: No. 12  1009 - 1012

Benson JR, Wakefield LM, Baum M and Colletta AA.  Synthesis and secretion of TGFß isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen.  Br J Cancer    1996; 74:  352 - 358

Benson JR, Baum M and Colletta AA.  Role of the TGFß’s in the anti-oestrogen response /resistance of human breast cancer. In: “The TGFß system in breast development, function and tumorigenesis” Journal of Mammary Gland Biology and Neoplasia  1996;  1: No. 4  379 - 387

Benson JR and Colletta AA.  Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.  Br J Cancer  1997;  75:  776 - 777

Benson JR   How to express oestrogen receptor activity.    Br J Cancer 1997;  76:  418 - 419

Benson JR    Tamoxifen in early breast cancer.    Lancet   1998;  352:  404 - 405

Benson JR and Osborne MP.   Radiation-induced sarcoma of the breast following conservation surgery.  Breast Cancer Res Treat   1999; 54: 293

Benson JR and Querci della Rovere G.   Classification of Isolated Tumor Cells and Micrometastases (comment).   CANCER   2000;  89:  No. 3   707 - 709

Benson JR and Purushotham A.   Trends in breast cancer incidence, survival and mortality.  Lancet   2000;  356:  590 - 593

Benson JR, Purushotham A and Warren R.  Screening and litigation - The rate of interval cancers is too high.    BMJ   2000;  321:  760 - 761 

Querci della Rovere G. and Benson JR   Tangential or parallel approach for fine needle aspiration cytology of breast lesions.  The Breast   2001;  10: 352 - 355

Benson JR.  Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated  findings of the National Surgical Adjuvant Breast and Bowel Project B-14 randomised trial (comment).   J Natl Cancer Inst  2001;  93 (19):  1493 - 1494

Benson JR and Querci della Rovere G.  The biological significance of ipsilateral local recurrence of breast cancer: determinant or indicator of poor prognosis. Lancet Oncology   2002;  3: 45 - 49

Benson JR  Recruitment of women into clinical trials. Lancet  2002; 359:  164 - 166

Benson JR.   Tamoxifen for breast cancer in hysterectomised women (letter). Lancet  2002;  360: 1784 - 1785

Benson JR. The effects of tamoxifen and estrogen on brain  metabolism in elderly women.  J Natl Cancer Inst 2002; 94:  67

Benson JR and Pitsinis V. Update on the clinical role of tamoxifen (review article)  Current Opinion in Obstetrics and Gynaecology   2003;  15:  13 - 23

Benson J R  The role of TGFß and breast carcinogenesis.  Lancet Oncol  2004;  5: No.4  229 - 239

Warren RML, Bobrow LG, Earl HM, Britton PB, Gopalan D, Purushotham AD, Wishart GW, Benson JR and Hollingworth W.  Can breast MRI help in the management of women with breast cancer treated by neoadjuvant chemotherapy ?  Br J Cancer  2004;  90: 1349 - 1360

Benson JR.  Skin-sparing mastectomy.  Cancer   2004; ;  101: No. 5  1099 - 1100

Benson JR.   The use of aromatase inhibitors in post-menopausal women with hormone receptor positive breast cancer.   Journal of Clinical Oncology 2005;  23:  6807 – 6809

Querci della Rovere G, Bonomi R, Ashley S and Benson JR.  Axillary staging in women with small invasive breast tumours. Eur J Surg Oncol  2006;  32:  733 – 737

Benson J.R. and Saeb-Parsy K.  Meta-analyses of cancer clinical trials – principles and pitfalls.   Commissioned article (mini-symposium) World Journal of Surgery 2006;  30:  1177 - 1183

Benson JR.   Sentinel node biopsy avoids unnecessary axillary dissection in breast cancer patients. Results of the Milan randomized trial (COMMENTARY). Lancet Oncology 2006; 7:  964 – 966

Books

Benson JR.  ‘TGFß and Cancer’  - book in Medical Intelligence Unitseries. [Landes Bioscience Publishers, Texas, USA]    1998  Chapters 1,2,4,7 and 8     [ISBN: 1-57059-539-9]

“Early Breast Cancer  - from screening to multidisciplinary management “ (Querci Della Rovere G, Warren R and  Benson JR. Eds.)  Taylor and Francis Publishers (2nd Edition) [ISBN 1 84184 384 9]  (published September 2005)  

“Oncoplastic and Reconstructive Surgery  of the  Breast   (Querci della Rovere G,  Benson JR, Breach N and Nava M. Eds)    Preface, editorial and chapters 1, 3, 15 and 17  Martin Dunitz Publishers 2004    [ISBN 1 84184 351 2]  (published March 2004 – best selling title; second edition in preparation)